Re-analysis of the first public SARS-CoV-2 transcriptomics data

Part 1.

The first public SARS-CoV-2 transcriptome from Blanco-Melo et. al. is now available and we took the opportunity to upload it onto our Omics Playground platform for analysis. The datasets consists of transformed lung alveolar (A459) and primary human lung epithelium (NHBE) infected with different Multiplicity of Infections (MOI) of SARS-CoV-2 (collected after 24h), as well as transformed lung alveolar (A459) cells infected with either respiratory syncytial virus (RSV) (collected after 24h) or Influenza A virus (IAV) (collected after 9h).

In order to replicate the main findings from this dataset, we first generated a wordcloud of the most significantly enriched gene sets in both SARS-CoV-2 infected cell types. In both cases, gene sets related to both viral infections and immune responses were particularly prevalent.

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