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Author: Axel Martinelli

RNA-seq transcriptome analysis of artisunate with Omics Playground
Case study

RNA-seq transcriptome analysis of the anti-inflammatory effect of artesunate on cerebral malaria

RE-ANALYSIS Cerebral malaria is the main cause of death in patients infected with Plasmodium falciparum. Artemisinin and its derivatives, such as artesunate (ATN), are the first-line treatment prescribed for severe …

How to convert FastQ files into read count tables
Blog Posts / Tutorial

How to convert FASTQ files into read count tables using Galaxy

This short guide is meant for biologists with little or no coding or bioinformatic experience and no access to a bioinformatician. It is not meant to be comprehensive, but rather …

Differentially expressed proteins in the KEGG proteasome pathway following PFN1 overexpression.
Case study

Profilin 1 and its role in proteasome inhibitors resistance

Browsing through the most recent proteomics dataset on the public PRIDE database, I came across this study (PXD033148) from Wang and colleagues at Xiangya Hospital of Central South University in …

Re-analysis of the transcriptomic data from a recently published article on the role of osteopontin on prostatic fibrosis and inflammation.
Case study

The Role of Osteopontin on Prostatic Fibrosis and Inflammation

For this post, I will re-analyse the transcriptomic data from a recently published article on the role of osteopontin on prostatic fibrosis and inflammation (Popovics et al, 2021). Fibrosis occurs …

The role of the microbiome on social interactions in mice
Case study

The role of the microbiome on social interactions in mice

The original article by Stilling et al (2018), described the association between gut microbiome composition and social behaviour in mice. They compared the social interaction of germ-free mice (GF, devoid …

Bioinformatic tools as collaborative tools in research teams.
Editorial

Bioinformatic Platforms as a collaborative tool.

The analysis of omics data involves the collaboration of biologists and bioinformaticians. They need each other to generate the data and analyse it. Biologists have a deep understanding of the …

Aging Insights from the GTEx Tissue Collection
Case study

Insights into Aging from the GTEx Tissue Collection

The Genotype-Tissue Expression program (GTEx) is an extensive collection of gene expression profiles from 54 different tissue sites across more than 1000 individuals. This data can provide various insights on …

IL-17A as a potential therapeutic target for osteoarthritis
Case study

IL-17A as a possible therapeutic target for Osteoarthritis

For this brief article, I have decided to re-analyse the RNA-seq data from a recently published paper on the osteoarthritis-like (OA-like) transcription changes induced in response to Interleukin-17 (IL-17) (Mimpen …

Editorial

How Omics Data Analysis Platforms can help solve the Analysis Bottleneck in Genomic Data Research

Amidst the talks of personalised medicine, it is easy to forget that cheap large-scale genome sequencing is a recent phenomenon that started in the early 2000’s with the development of …

Glucocorticoid Resistance in Multiple Myeloma: a Dataset Re-analysis
Case study

Glucocorticoid Resistance in Multiple Myeloma: a Dataset Re-analysis

For this post, I decided to re-analyse a dataset from a recent article by Logie et al (2021) using our Omics Playground platform. Multiple Myeloma (MM) is a malignancy that …

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Recent Posts

  • The Power of Centralized and Collaborative Data Analytics: Decreasing Proteomics Data Analysis Time by 62% to Scale Breakthroughs in Cancer Care
  • Building a robust Bioinformatics Infrastructure: Streamlining RNA-seq data analysis to facilitate groundbreaking Gene & Cell R&D
  • Accelerate Biotech Innovation: Impacts of Modern Transcriptomics Data Analytics Platforms
  • RNA-seq transcriptome analysis of the anti-inflammatory effect of artesunate on cerebral malaria
  • 9 factors you should consider when choosing RNA-seq analysis and visualization software

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