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Category: Scientific Insights

Welcome to “Scientific Insights,” where we showcase the applications of Omics Playground, our RNA-Seq and proteomics data analysis software.
Here we re-analyze data from existing publications to see what additional biological insights our platform can provide. Join us on a journey of scientific discovery and learn how to turn your data into insights with Omics Playground.

Combining Multi-Omics Factorization Methods for Robust Biomarker Identification
Blog Posts / Scientific Insights

Combining Multi-Omics Factorization Methods for Robust Biomarker Identification

Combining Multi-Omics Factorization Methods for Robust Biomarker Identification Written by Ivo Kwee⏱ 5 min read Introduction Multi-omics biomarker identification is crucial for advancing biomedical research and personalized medicine. Computational genomic …

Thumbnail rna seq use case Almaden and BigOmics
Scientific Insights

From Raw Data to Therapeutic Insights: End-to-End RNA-Seq Analysis of IL-17A in Osteoarthritis

USE CASE From Raw Data to Therapeutic Insights: End-to-End RNA-Seq Analysis of IL-17A in Osteoarthritis Written by Axel Martinelli in collaboration with Almaden Genomics. Introduction In 2021 Mimpen et al. …

STL001 blog post thubmnail
Scientific Insights

Synergizing mTOR Inhibitors with STL001’s Enhanced Modes of Action and Tetrandrine Potential

Advancing Cancer Therapeutics: Synergizing mTOR Inhibitors with STL001’s Enhanced Modes of Action and Tetrandrine Potential Written by Axel Martinelli in collaboration with Lexogen⏱ 6 min read FOXM1, a transcription factor …

Sars Cov2 Virus Model
Scientific Insights

The Potential Role of SSX2 and Trametinib in MERS and SARS

The Potential Role of SSX2 and Trametinib in MERS and SARS Published on February 25, 2020⏱ 7 min read Introduction In my previous post on Finding Potential Biomarkers And Therapeutic Drugs …

Aging Insights from the GTEx Tissue Collection
Scientific Insights

Insights into Aging from the GTEx Tissue Collection: Exploring Biomarkers of Aging and Aging Pathways

Insights into Aging from the GTEx Tissue Collection Exploring Biomarkers of Aging and Aging Pathways Written by Axel Martinelli⏱ 9 min read Last updated on December 6th, 2024Published on August …

Re-analysis Sar Cov2 datasets thumbnail image
Scientific Insights

Re-analysis of the first public SARS-CoV-2 transcriptomics data

Re-analysis of the first public SARS-CoV-2 transcriptomics data Last updated on November 29, 2024Published on April 14th, 2020 Written by Axel Martinelli⏱ 10 min read Introduction The first public SARS-CoV-2 …

Comparison of transcriptomics and proteomics data indicated that in both datasets (X-axis: proteomics, Y-axis: transcriptomics) pro-inflammatory proteins, including several cytokines, were upregulated (Figure 1A). Significant negative correlation with the sarcoidosis protein expression profile in the GSEA-like plot (Figure 1B).
Scientific Insights

Reanalyzing Olink Proteomics Data with Omics Playground: Uncovering Therapeutic Drug Potential for Sarcoidosis

Reanalyzing Olink Proteomics Data with Omics Playground: Uncovering Therapeutic Drug Potential for Sarcoidosis Published on October 14th, 2024by Axel Martinelli ⏱ 5 min read Introduction Omics Playground supports a wide …

brain in neurodegenerative diseases studies
Scientific Insights

Comparative analysis and Identification of Therapeutic Targets for Neurodegenerative Diseases: a Re-Analysis

Comparative analysis and Identification of Therapeutic Targets for Neurodegenerative Diseases: a Re-Analysis Learn about the similarities and differences between Alzheimer’s disease and Parkinson’s disease and how to identify therapeutic targets …

RNA-seq transcriptome analysis of artisunate with Omics Playground
Scientific Insights

RNA-seq transcriptome analysis of the anti-inflammatory effect of artesunate on cerebral malaria

RNA-seq transcriptome analysis of the anti-inflammatory effect of artesunate on cerebral malaria Re-Analysis Published on April 25th, 2023by Axel Martinelli, PhD ⏱ 11 min read Introduction to the Cerebral Malaria …

Differentially expressed proteins in the KEGG proteasome pathway following PFN1 overexpression.
Scientific Insights

Profilin 1 and its role in proteasome inhibitors resistance

Profilin 1 and its role in proteasome inhibitors resistance Published on May 19th, 2022Written by Axel Martinelli⏱ 2 min read Introduction Browsing through the most recent proteomics dataset on the …

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